Familial clustering of a disease is defined as the occurrence of the disease within some families in excess of what would be expected from the occurrence in the population. It has been demonstrated for several cancer types, ranging from rare cancers as the adenomatosis-coli-associated colon cancer or the Li-Fraumeni syndrome to more common cancers as breast cancer and colon cancer. Familial clustering, however, is merely an epidemiological pattern, and it does not tell whether genetic or environmental causes or both in (...) combination are responsible for the familial clustering. Familial clustering may be due to genetic predisposition to the disease, but exposure to environmental factors — shared by members of some families, but not by members of other families — may also cause familial clustering and hence mimic genetic inheritance in the study of nuclear families. Based on assumptions regarding the individual steps in the biological process starting with exposure to carcinogens and ending with death from disseminated cancer we suggest that genetic and environmental factors may both be involved in most of these steps. The present paper focuses on research methodologies necessary to discriminate between the effect of genes and family environment in the development of cancer. (shrink)

The aim of this paper is to present and discuss nurses’ and physicians’ comments in a questionnaire relating to patients’ transition from curative treatment to palliative care. The four-page questionnaire relating to experiences of and attitudes towards communication, decision-making, documentation and responsibility of nurses and physicians and towards the competence of patients was developed and sent to a random sample of 1672 nurses and physicians of 10 specialties. The response rate was 52% , and over one-third made comments. The respondents (...) differed in their comments about three areas: the concept of palliative care, experiences of unclear decision-making and difficulties in acceptance of the patient’s situation. The responses are analysed in terms of four ethical theories: virtue ethics, deontology, consequentialism and casuistry. Many virtues considered to be appropriate for healthcare personnel to possess were invoked. Compassion, honesty, justice and prudence are especially important. However, principles of medical ethics, such as the deontological principle of respect for self-determination and the consequence of avoidance of harm, are also implied. Casuistry may be particularly helpful in analysing certain areas of difficulty—namely, what is meant by “palliative care”, decision-making and accepting the patient’s situation. Keeping a patient in a state of uncertainty often causes more suffering than necessary. Communication among the staff and with patients must be explicit. Many of the staff have not had adequate training in communicating with patients who are at the end of their life. Time for joint reflection has to be regained, and training in decision-making is essential. In our opinion, palliative care in Sweden is in need of improvement. (shrink)

Aktualnejshaya problema segodnyashnego dnya - vyhod iz sistemy globalnyh krizisov, s kotorymi stolknulos naselenie Zemli, i perehod k "obschestvu razumnogo potrebleniya," obschestvu znaniya. Ogromnuyu rol v etom protsesse igraet obrazovanie - sotsialnyj institut, odnoj iz zadach kotorogo yavlyaetsya sohranenie i translyatsiya znaniya v sotsialnyh sistemah. A chto takoe informatsiya? Iznachalno ee teoriya voznikla dlya nuzhd tehniki. Iz-za etogo mnogie ee aspekty ostalis ne razvitymi, potomu chto oni prosto ne byli vazhnymi dlya tehnicheskih sistem. Primenenie teorii informatsii k biologicheskim sistemam uzhe (...) zastavilo zanyatsya voprosom vozniknoveniya novoj informatsii. A rabota s sotsialnymi sistemami vydvinula takie ponyatiya, kak tsennost, effektivnost, slozhnost informatsii i t. d. Bolee polnyj podhod k teorii informatsii, v svoyu ochered, pozvolyaet najti resheniya ryada problem v teorii sotsialnyh sistem, v chastnosti v obrazovanii, i pokazat puti optimizatsii etih protsessov. (shrink)

Bringing together essays that span the career of I.A. Richards--as both literary critic and pedagogue--this collection provides a much-needed re-introduction to a thinker whose works have been largely neglected of late. Carefully chosen, edited, and annotated, the selections make accessible a wide array of Richards's ideas on language and learning, focusing on his discussion of literacy, his critique of positivist linguistics, his explorations of C.S. Peirce's semiotics, and his theory of translation, which led not only to his well-known analysis of (...) the structure and foundation of metaphor but to one of the earliest and most cogent formulations of reader-response theory. Berthoff's editing eliminates the distracting elements of Richards's style--the digressions and obscure allusions that have often hindered readers, and have in part contributed to the neglect his work has met with in recent years--while identifying and illuminating the chief principles of his critical thought and practice. Organized in four parts--Practical Criticism, The Philosophy of Rhetoric, The Meaning of Meaning, and Design for Escape--the book offers a lucid introduction to Richards's writings, with valuable headnotes to each section and a unique index of "speculative instruments" that examines the principal ideas Richards thought with. Readers are certain to find this volume essential to an understanding of Richards's "practical criticism," and invaluable in sharpening and re-directing their own thoughts on current linguistic practice, literary criticism, and educational theory. (shrink)